Fire Capt. Jaime Moore says oil spilled early Thursday over approximately half a mile and was knee-high in some parts of the industrial area of Atwater Village near the border of Glendale.
A handful of commercial businesses were affected, as well as a strip club that was evacuated.
Moore says four people at a medical business were evaluated with respiratory complaints, and two people were transferred to a hospital.
An environmental cleaning company is sopping up the remaining oil and will use high-pressure hoses to wash the streets. Officials previously said 50,000 gallons had spilled.
Moore says the pipe burst at a transfer pumping station along a pipeline that runs from Bakersfield to Texas.